Different paths to the modern state in Europe: the interaction between domestic political economy and interstate competition

Theoretical work on state formation and capacity has focused mostly on early modern Europe and on the experience of western European states during this period. While a number of European states monopolized domestic tax collection and achieved gains in state capacity during the early modern era, for others revenues stagnated or even declined, and these variations motivated alternative hypotheses for determinants of fiscal and state capacity. In this study we test the basic hypotheses in the existing literature making use of the large date set we have compiled for all of the leading states across the continent. We find strong empirical support for two prevailing threads in the literature, arguing respectively that interstate wars and changes in economic structure towards an urbanized economy had positive fiscal impact. Regarding the main point of contention in the theoretical literature, whether it was representative or authoritarian political regimes that facilitated the gains in fiscal capacity, we do not find conclusive evidence that one performed better than the other. Instead, the empirical evidence we have gathered lends supports to the hypothesis that when under pressure of war, the fiscal performance of representative regimes was better in the more urbanized-commercial economies and the fiscal performance of authoritarian regimes was better in rural-agrarian economie

Citizen Attitudes Toward Traditional and State Authorities: Substitutes or Complements?

Do citizens view state and traditional authorities as substitutes or complements? Past work has been divided on this question. Some scholars point to competition between attitudes toward these entities, suggesting substitution, whereas others highlight positive correlations, suggesting complementarity. Addressing this question, however, is difficult, as it requires assessing the effects of exogenous changes in the latent valuation of one authority on an individual’s support for another. We show that this quantity—a type of elasticity—cannot be inferred from correlations between support for the two forms of authority. We employ a structural model to estimate this elasticity of substitution using data from 816 villages in the Democratic Republic of Congo and plausibly exogenous rainfall and conflict shocks. Despite prima facie evidence for substitution logics, our model’s outcomes are consistent with complementarity; positive changes in citizen valuation of the chief appear to translate into positive changes in support for the government.</p

Components of the Engulfment Machinery Have Distinct Roles in Corpse Processing.

Billions of cells die in our bodies on a daily basis and are engulfed by phagocytes. Engulfment, or phagocytosis, can be broken down into five basic steps: attraction of the phagocyte, recognition of the dying cell, internalization, phagosome maturation, and acidification. In this study, we focus on the last two steps, which can collectively be considered corpse processing, in which the engulfed material is degraded. We use the Drosophila ovarian follicle cells as a model for engulfment of apoptotic cells by epithelial cells. We show that engulfed material is processed using the canonical corpse processing pathway involving the small GTPases Rab5 and Rab7. The phagocytic receptor Draper is present on the phagocytic cup and on nascent, phosphatidylinositol 3-phosphate (PI(3)P)- and Rab7-positive phagosomes, whereas integrins are maintained on the cell surface during engulfment. Due to the difference in subcellular localization, we investigated the role of Draper, integrins, and downstream signaling components in corpse processing. We found that some proteins were required for internalization only, while others had defects in corpse processing as well. This suggests that several of the core engulfment proteins are required for distinct steps of engulfment. We also performed double mutant analysis and found that combined loss of draper and αPS3 still resulted in a small number of engulfed vesicles. Therefore, we investigated another known engulfment receptor, Crq. We found that loss of all three receptors did not inhibit engulfment any further, suggesting that Crq does not play a role in engulfment by the follicle cells. A more complete understanding of how the engulfment and corpse processing machinery interact may enable better understanding and treatment of diseases associated with defects in engulfment by epithelial cells

Candidate dsRNA Screen Results.

<p>Candidate dsRNA Screen Results.</p

Croquemort becomes enriched in the follicle cells during engulfment and has defects in follicle cell health.

<p>(A-C) Egg chambers expressing <i>UAS-GFP</i> driven by <i>Crq-GAL4</i> (<i>Crq-GAL4/CyO; UAS-mCD8-GFP/TM2</i>) stained with DAPI (cyan). (A-A’) Healthy egg chambers show little to no Crq expression in the germline or follicle cells. (B-B’) Phase 3 egg chambers show an increase in Crq expression in the follicle cells. (C-C’) Phase 5 egg chambers show considerably more Crq expression in the remaining follicle cells. (D-E) Egg chambers from starved flies stained with DAPI (cyan). (D) A wild-type egg chamber (<i>w</i>^<i>1118</i>) has a germline surrounded by a monolayer of healthy follicle cells. (E) <i>crq</i> null egg chambers (<i>crq</i>^<i>KO</i>) show undead germline with no remaining healthy follicle cells. (F) Quantification of the number of “undead” egg chambers per 100 ovarioles in the indicated genotypes. Scale bar is 50μm.</p